During this Science Café, two researchers from our WP 5 where invited to present their research focus to the young experts of Euro Youth Mental Health. As always, the Science Cafés offer both young experts and researchers plenty of room for questions, feedback and discussions.
Winni Schalkwijk talked about the immune system in relation to mental health. She started by exchanging ideas about the meaning of resilience. After that Winni explained how she focuses on the biological component of resilience meaning: ‘in the face of challenges’, ‘coping with them’ or ‘preventing long-term negative impacts’. Two main systems are involved: the stress system and the immune system. The stress system responds physically to threats or challenges around us. Closely connected to this is the immune system, which is a bit more subtle and restores internal balance (also called “the outside within”). These systems are closely connected, and interacting with environmental (psychological and physical) stressors. Winni’s hypothesis is that the immune system is involved in resilience to environmental risk factors for mental health problems. She and her team want to know more about the developmental part and would like to measure immune responses in a reliable way. They do this for instance via inflammatory signalling molecules from the blood and DNA extracted from immune cells (epigenetics).
Next, researcher Bochao Lin informed the young experts on her study about the prediction of mental health trajectories in psychotic experiences. Specific genes seem to be involved and there are often polygenic factors contributing to mental distress. Bochao already identified exposures for psychotic experiences from the UK biobank; the results show 148 important variables contributing to psychotic experiences. Early intervention is crucial because it can limit the accumulation of harmful exposures and disrupt sequences of events that would otherwise lead to greater harm. A proactive approach helps in minimizing risks and improving overall outcomes for individuals and systems exposed to potentially harmful factors. Bochao invited young experts to think along about what (environmental) factors would be interesting to investigate in a longitudinal study. Young experts mentioned amongst others: the use of devices and social media, growing up in a different culture and profession, income and relationship of parents.
*More about Youth-GEMs and the different work packages can be found via:
Our Approach – Youth-GEMs. Interested in co-creating with young experienced experts? Find out more information via our partner Euro Youth Mental health on www.eymh.org.
