As part of the Youth-GEMs clinical study, we collect blood samples to learn more about the biological processes related to young people’s mental health. These samples allow researchers to measure different types of biological signals in the body, including genetic information, proteins, small molecules involved in metabolism, and markers of the immune system. Examples include substances such as alpha-2-macroglobulin (A2M), soluble urokinase-type plasminogen activator receptor (suPAR), and complement proteins (C5b-9), which can give clues about how the body responds to stress, inflammation, and other factors linked to mental health.
For participants who prefer not to give a blood sample, we can also collect genetic information using a saliva sample. This is a simple and non-invasive alternative.
Collecting this biological information is an important part of the Youth-GEMs project. The goal of the study is to better understand how genetic factors and environmental influences work together in the development of mental health difficulties in young people.
The genetic analyses will be carried out by research teams in the UK, mainly in Exeter and Cardiff. These analyses look at the entire genetic code of participants to identify patterns that may be linked to mental health.
Other biological measurements, such as proteins, metabolic markers, and immune signals, will be analysed by partners in Ireland. These results will be combined with other information collected in the clinical study, such as questionnaires and assessments, to build a more complete picture of youth mental health.
Together, this research will help scientists better understand why some young people develop mental health difficulties and how we might improve early detection and support in the future.